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W E L C O M E !

"Membrane proteins play key roles in human health, contributing to cellular signaling, immunity, and material exchange. Additionally, this class of proteins is a major target for commercial drug molecules. We are therefore dedicated to unveiling their hidden dynamics using single-molecule tools and molecular dynamics simulation, which could contribute to the development of effective therapeutic interventions. Specifically, our focus is on understanding how membrane proteins fold into their native structures and how they interact with other proteins and biomolecules. We are also expanding our research scope to include fields such as protein oxidative damage and proteomics."

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News Updates

2025

  • 06 | Eojin's recent work as a co-first author has been published in Nano Today (Link). Using molecular dynamics simulations, he characterized the detailed dynamics of anti-DR5 nanobody complexes that drive apoptotic cancer cell death. Congratulations!

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  • 05 | Our invited review article has been published in Annual Review of Biophysics (Link). Bhashini and Duyoung authored an in-depth review on membrane protein folding. Congratulations!

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  • 03 | Welcome, Minseung and Arim! We are excited to have you join the lab as a PhD student and an undergraduate intern, respectively!

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  • 02 | Seoyoon received an Outstanding Paper Award for her recent work on "a hidden pathway of oxidative protein damage" at the 2025 Graduate Symposium and Excellent Research Awards. Congratulations!

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  • 01 | Our collaborative work on the rational design of photosensitizers for cancer treatment has been published in Advanced Science (Link). Congratulations!

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2024

  • 12 | A recent study by Seoyoon, Eojin, Victor, and Bhashini has been published in Nature Communications (Link). In their research, they uncovered a hidden pathway of protein damage via a novel oxygen-confined photooxidation mechanism. Congratulations on this remarkable achievement!

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  • 05 | Bhashini's recent work as a co-first author has been published in Nature Communications (Link). In this study, she observed the effects of oxidative photocatalysis on membrane protein folding at single-molecule resolution. Congratulations!

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  • 03 | Welcome, Shi Ho! We are excited to have you join us as our lab's new Postdoc.

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  • 02 | Duyoung's invited review article has been published in Biochemical Society Transactions (Link), titled "Folding speeds of helical membrane proteins". Congratulations!

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  • 02 | Seoyoon received the Best Paper Award for her outstanding work on "the speed limit of membrane protein folding" at the 2024 Graduate Symposium and Excellent Research Awards. Congratulations!

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  • 01 | Eojin received an Outstanding Poster Award for his work on "protein oxidative damage" at the 4th Biological Physics Symposium of the Korean Physical Society. Congratulations!

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  • 01 | Our invited book chapters have been published in a volume of Methods in Enzymology (Link Link), titled "Magnetic Tweezers for the Study of Protein Structure and Function". The chapters, authored by Seoyoon, Daehyo, and Duyoung, provide step-by-step protocols for our single-molecule tweezer approach to membrane protein structural dynamics. Congratulations!

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2023

  • 11 | Eojin received an Outstanding Presentation Award for his work on "protein aging" at the Fall Meeting of the Korean Physical Society. Congratulations!

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  • 11 | Our invited preview article has been published in Structure (Link) as part of the 30th anniversary special issue. Eojin and Duyoung wrote this piece, putting recent single-molecule findings on a protein folding chaperone into perspective.

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  • 06 | Our invited review article has been published in Journal of Molecular Biology (Link) as part of a special issue titled "Changing Shape of Molecules and Changing Landscape of Molecular Biology". Bhashini and Duyoung authored an in-depth review on single-molecule force spectroscopy of membrane protein folding. Congratulations!

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  • 05 | Our work on a new single-molecule method and membrane protein folding has been published in eLife (Link). In this study, Seoyoon, Daehyo, and Bhashini developed a robust magnetic tweezer approach and characterized the "speed limit" of membrane protein folding. Congratulations!

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  • 02 | Welcome, Jeonghyun! We are excited to add another new color to the lab.

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2019~2022

  • 2022.09 | Eojin continues his undergraduate research in our group as a PhD student.

  • 2022.02 | Welcome Poornima, our newest addition to the group as a PhD student!​

  • 2021.04 | Welcome, Bhashini! We are excited to have you join us as a PhD student.

  • 2021.03 | Daehyo has begun his PhD program to further pursue his undergraduate research.

  • 2021.02 | Victor has joined our group as a PhD student. Welcome aboard!​​

  • 2020.01 | Razzak and Seoyoon have joined as the lab's first Postdoc and PhD student. Welcome!​

  • 2019.10 | Duyoung's work on membrane protein folding has been published in Science (Link). Congratulations!

  • 2019.10 | Our lab has officially opened at UNIST!

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